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Latest company case about Analysis of PCR Laboratory Construction Standards

Analysis of PCR Laboratory Construction Standards

PCR laboratories play a pivotal role in fields such as biomedical testing and disease diagnosis. As a professional purification equipment manufacturer, Guangzhou Cleanroom Construction Co., Ltd. deeply understands the significance of constructing PCR laboratories that meet standards. Today, we will take you on an in - depth exploration of the construction standards for PCR laboratories. I. Regional Division Standards A PCR laboratory is generally divided into four main areas: the reagent preparation area, the sample preparation area, the amplification area, and the product analysis area. Each area must be completely independent with clear physical separations to prevent cross - contamination between different areas. For example, buffer rooms are set up to block the direct flow of air. The buffer rooms should be equipped with hand - washing facilities and wardrobes to ensure that personnel can take proper protection and cleanliness when entering different areas. II. Airflow and Pressure Control Standards Airflow organization and pressure gradients are crucial for ensuring laboratory safety. The air pressure should show a decreasing trend from the reagent preparation area to the product analysis area, creating a negative - pressure state. This can ensure that aerosols containing pathogens do not spread to other areas. The high - efficiency purification equipment produced by Guangzhou Cleanroom Construction Co., Ltd. can precisely adjust the airflow and pressure in each area, effectively maintaining the stability of the laboratory's airflow and pressure gradients. III. Purification and Disinfection Standards Air purification and disinfection in the laboratory are of utmost importance. High - efficiency particulate air (HEPA) filters should be used to filter the air, with a filtration efficiency of over 99.97% to remove microorganisms and particulate matter in the air. At the same time, regular disinfection should be carried out. Surfaces such as walls, floors, and laboratory benches need to be wiped with appropriate disinfectants. In terms of the selection of disinfection equipment, ultraviolet disinfection lamps and chemical disinfection equipment should be used in a reasonable combination. IV. Electrical and Lighting Standards The electrical system needs to meet the power requirements of laboratory equipment and should also be equipped with leakage protection and grounding measures to ensure electrical safety. In terms of lighting, sufficient and uniform light should be provided to avoid shadows that may affect experimental operations. Generally, flicker - free and glare - free LED lamps are used to ensure a comfortable and safe experimental environment. Constructing a PCR laboratory that meets standards is the foundation for ensuring the accuracy of experiments and the safety of personnel. With professional technology and high - quality products, Guangzhou Cleanroom Construction Co., Ltd. provides comprehensive support for your PCR laboratory construction. If you have relevant construction needs, please feel free to contact us at any time to jointly create a high - quality PCR laboratory.  
2025-01-24
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Latest company case about In - depth Analysis of Chemical Laboratory Construction Engineering: Creating a Professional Research Space

In - depth Analysis of Chemical Laboratory Construction Engineering: Creating a Professional Research Space

In the field of scientific research, the chemical laboratory, as a crucial place for conducting various chemical experiments, the quality of its construction project directly affects the progress of scientific research work. Guangzhou Cleanroom Construction Co., Ltd., as a professional purification equipment manufacturer, will take you to deeply understand the mysteries of chemical laboratory construction engineering today. I. Preliminary Planning is the Cornerstone Precise planning is indispensable in the early stage of chemical laboratory construction. According to the functional requirements of the laboratory, such as different experimental directions like organic chemistry, inorganic chemistry, and analytical chemistry, the areas should be reasonably divided. Considering the harmful gases, waste water, etc. that may be generated during the experiment, the planning of the ventilation system and drainage system should be carried out first. At the same time, the spatial layout of the laboratory should be scientifically designed to ensure that the experiment benches and instrument equipment are placed reasonably, and the operation of personnel is convenient and safe. II. The Construction Process is Crucial Step by Step Basic Engineering Construction: It includes the treatment of the ground, walls, and ceiling. The ground needs to have anti - slip and corrosion - resistant properties, and epoxy self - leveling floors are commonly used. The walls should choose fire - proof, moisture - proof, and easy - to - clean materials, such as color steel plates. The ceiling needs to meet the requirements of fire protection and ventilation. Ventilation System Installation: This is one of the core systems of the chemical laboratory. High - efficiency ventilation equipment can timely discharge the harmful gases generated during the experiment and ensure the health of experimental personnel. The purification equipment produced by Guangzhou Cleanroom Construction Co., Ltd. plays an important role in the ventilation system, and its powerful purification ability can effectively filter harmful gases. Water Supply and Drainage System Construction: Reasonably design the water supply and drainage pipelines to ensure the smooth supply of experimental water and the discharge of waste water. For waste water containing chemical substances, special treatment should be carried out and discharged after meeting the discharge standards. Electrical System Laying: Meet the power consumption requirements of various instrument equipment in the laboratory. At the same time, considering safety factors, set up measures such as leakage protection and grounding. III. Technical Difficulties and Solutions Harmful Gas Treatment: The harmful gases generated in chemical experiments have complex components and are difficult to handle. We adopt advanced purification technologies and equipment, such as activated carbon adsorption, photocatalytic oxidation, etc., to effectively decompose and purify harmful gases. Temperature and Humidity Control in the Laboratory: Some chemical experiments have extremely high requirements for temperature and humidity. By installing an intelligent temperature and humidity control system, the temperature and humidity in the laboratory are monitored and adjusted in real - time to ensure a stable experimental environment. Choosing a professional construction team and high - quality equipment is the key to creating a high - quality chemical laboratory. With rich experience and excellent products, Guangzhou Cleanroom Construction Co., Ltd. is committed to providing you with the most complete chemical laboratory construction solutions. If you have relevant needs, please feel free to contact us.
2025-01-24
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Latest company case about Engineering Construction Standards for CDC Laboratories: Building a Solid Defense Line for Public Health

Engineering Construction Standards for CDC Laboratories: Building a Solid Defense Line for Public Health

As Guangzhou Cleanroom Construction Co., Ltd., which is dedicated to the production of purification equipment, we deeply understand the crucial role of Centers for Disease Control and Prevention (CDC) laboratories in the field of public health. These laboratories undertake important tasks such as disease monitoring, pathogen detection, and scientific research. Their engineering construction standards are directly related to the accuracy of test results and public health safety. Below, we will introduce the key engineering construction standards for CDC laboratories in detail. I. Building Layout Standards 1. Clear Functional Zoning It is necessary to strictly divide the clean area, semi - contaminated area, and contaminated area. The clean area is used for storing reagents, office work, etc.; the semi - contaminated area serves as a buffer zone where personnel change their protective equipment; and the contaminated area is the core operation area for sample testing, pathogen cultivation, etc. Reasonable passageways and barriers are used to separate different areas to prevent cross - contamination. 2. Rational Flow Design The flow routes of personnel, samples, and items should be clearly planned. For example, the path of samples from receipt, transfer to testing should avoid crossing the regular walking routes of personnel to reduce the risk of contamination. At the same time, a special waste passage should be set up to ensure that contaminated waste can be transported out of the laboratory safely and in a timely manner. II. Equipment and Facility Standards 1. Precise and Reliable Detection Equipment Equip with advanced and precise detection equipment, such as PCR amplifiers, high - performance liquid chromatographs, etc., to meet the detection needs for various pathogens and pollutants. These devices need to be calibrated and maintained regularly to ensure the accuracy and repeatability of test results. 2. Efficient and Stable Purification Equipment To ensure the cleanliness of the experimental environment, efficient purification equipment is essential. The high - efficiency air filters produced by our company can effectively filter dust, microorganisms, and other pollutants in the air. Combined with a reasonable ventilation system, the laboratory can meet the corresponding cleanliness requirements, such as the common Class 10,000 or Class 100,000 cleanliness levels. In addition, biosafety cabinets need to be equipped to provide a safe operating space for operators and prevent the spread of pathogens. III. Environmental Control Standards 1. Precise Temperature and Humidity Control The temperature and humidity in the laboratory have a significant impact on experimental results. Generally, the temperature needs to be controlled between 20 - 26°C, and the humidity is maintained at 40% - 60%. By installing a professional temperature and humidity control system, the environmental parameters are monitored and adjusted in real - time to ensure the stability of experimental conditions. 2. Strict Pressure Difference Control To prevent the spread of polluted air, a reasonable pressure difference should be maintained between different areas. For example, the contaminated area maintains a negative pressure relative to the semi - contaminated area, and the semi - contaminated area maintains a negative pressure relative to the clean area. In this way, air can flow from the clean area to the contaminated area, avoiding the reverse spread of pollutants. IV. Safety Protection Standards 1. Electrical Safety Assurance Adopt a safe and reliable electrical system, equipped with leakage protection devices, emergency lighting, etc. At the same time, the electrical lines are laid reasonably to avoid safety accidents caused by problems such as aging and short - circuit of the lines. 2. Biosafety Protection Laboratory staff need to be equipped with complete personal protective equipment, such as protective clothing, goggles, gloves, etc. In addition, the laboratory should formulate strict biosafety management systems, including sample management, waste disposal, etc., to effectively prevent biological hazards during the experimental process. The high - standard construction of CDC laboratories is an important foundation for ensuring public health safety. With professional purification equipment and rich industry experience, Guangzhou Cleanroom Construction Co., Ltd. is committed to providing high - quality products and services for the construction of CDC laboratories. If you have any needs in the engineering construction of CDC laboratories, please feel free to contact us at any time. Let's work together to contribute to the public health cause.
2025-01-23
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Latest company case about Cleanroom Cleanliness and Microbial Detection: The Key Line of Defense for Protecting Production Quality

Cleanroom Cleanliness and Microbial Detection: The Key Line of Defense for Protecting Production Quality

As Guangzhou Cleanroom Construction Co., Ltd., which is dedicated to the production of purification equipment, we deeply understand the significance of cleanrooms for numerous industries. In fields with extremely high requirements for the production environment, such as pharmaceuticals, food, and electronics, the cleanliness of cleanrooms and microbial detection are the core elements to ensure product quality and safety. I. The Importance of Cleanliness and Microbial Detection 1. Product Quality Assurance Take the manufacturing of electronic chips as an example. Tiny dust particles can cause chip short - circuits or other performance issues. In pharmaceutical production, microbial contamination directly threatens the safety and effectiveness of drugs. Ensuring that the cleanliness of the cleanroom meets the standards and strictly detecting microorganisms are the cornerstones of producing high - quality products. 2. Compliance with Regulatory Standards Countries and various industries have formulated strict cleanroom standards and microbial limit requirements. For example, in the pharmaceutical industry, it is necessary to follow the GMP (Good Manufacturing Practice) standards. Only by meeting these regulatory requirements can enterprises produce legally and compliantly. II. Cleanliness Detection Methods 1. Dust Particle Counter This is a commonly used device for detecting cleanliness. It can accurately measure the number of dust particles of different particle sizes in the air through the principle of light scattering. According to the level requirements of the cleanroom, the number of particles per cubic meter of air is counted to determine whether it meets the corresponding cleanliness level. 2. Aerobic Colony Counter Although it is mainly used for microbial detection, it can also reflect cleanliness from the side. It collects the microorganisms floating in the air onto Petri dishes or culture media by extracting a certain volume of air. After cultivation, the number of colonies is counted to understand the content of microorganisms in the air, indirectly reflecting the cleanliness situation. III. Microbial Detection Methods 1. Settling Plate Method Place Petri dishes filled with culture media at specific positions in the cleanroom. Open the lids and expose them for a certain period of time, allowing the microorganisms in the air to naturally settle onto the culture media. Then, cultivate and count the colonies. This is a simple and intuitive detection method that can detect the microbial contamination in the air in a stationary state. 2. Swab Sampling Method For the microbial detection of the surfaces of equipment, walls, and other objects, the swab sampling method is commonly used. Dip a sterile cotton swab in an appropriate sampling solution, wipe the surface of the object, and then put the cotton swab into the culture medium for cultivation. The degree of microbial contamination on the object surface is judged by counting. IV. The Interrelationship between Cleanliness and Microbial Detection In a cleanroom with high cleanliness, the possibility of the presence of microorganisms is relatively low. Since dust particles may carry microorganisms, reducing the number of dust particles also reduces the carriers of microorganisms. The results of microbial detection can also reflect the maintenance of cleanliness. If the microorganisms exceed the standard, it is likely that there are problems with the purification system of the cleanroom or improper operations by personnel, affecting the cleanliness. V. Professional Services of Guangzhou Cleanroom Construction Co., Ltd. 1. Provision of High - Quality Equipment We produce various purification equipment, such as high - efficiency air filters and air showers, which can effectively improve the cleanliness of cleanrooms and reduce the entry of dust particles and microorganisms from the source. 2. Customized Detection Solutions Based on cleanrooms in different industries and of different scales, we customize cleanliness and microbial detection solutions for customers to ensure the scientificity and effectiveness of the detection. 3. Technical Support and Training We provide professional technical personnel to provide solutions to the problems encountered by customers during the detection process and train relevant operators to enable them to master the detection methods and procedures proficiently. The cleanliness of cleanrooms and microbial detection are closely linked and are key links in the production of many industries. Guangzhou Cleanroom Construction Co., Ltd. is willing to work with you to create a safe, efficient, and clean production environment with professional products and services. If you have any relevant needs or questions, please feel free to contact us at any time!
2025-01-23
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Latest company case about Full Analysis of the Standard Operating Procedure for Settling Bacteria Testing in Pharmaceutical Plant Purification Workshops

Full Analysis of the Standard Operating Procedure for Settling Bacteria Testing in Pharmaceutical Plant Purification Workshops

As Guangzhou Cleanroom Construction Co., Ltd., which is dedicated to the production of purification equipment, we are well aware of the significance of the environment in pharmaceutical plant purification workshops for drug quality. Settling bacteria testing is a crucial part of evaluating the microbial contamination status in purification workshops. Today, we will introduce the standard operating procedure in detail. Pre - operation Preparation Personnel Preparation: Operators must undergo professional training, be familiar with the settling bacteria testing process and relevant microbiological knowledge. They should wear clean clothes, masks, hats, and gloves that meet the requirements of the purification workshop to avoid the interference of microorganisms carried by themselves on the test results. Instrument and Reagent Preparation: Prepare calibrated Petri dishes to ensure they are sterile and undamaged. Prepare corresponding culture media, such as Soybean - Casein Digest Agar Medium, etc., and prepare and sterilize them according to the specified methods. At the same time, prepare tools for marking and recording, such as marker pens, record forms, etc. Environmental Preparation: Before the test, ensure that the purification system in the purification workshop has been operating normally for a sufficient time to make the environmental parameters such as air flow, temperature, and humidity in the workshop reach a stable state. Turn off unnecessary equipment, doors, and windows, and reduce personnel movement to avoid the influence of external factors on the test environment. Specific Operation Steps Sampling Point Layout: According to the area of the pharmaceutical plant purification workshop, the division of functional areas, and relevant standard requirements, reasonably determine the sampling points. Generally, set sampling points at the four corners, the center of the workshop, and near key production equipment to ensure that the microbial distribution in the workshop can be comprehensively reflected. Placing Petri Dishes: Place the prepared Petri dishes horizontally at the sampling points, open the Petri dish lids, expose the surface of the culture medium to the air, and start timing. The exposure time is determined according to relevant standards and actual situations, usually ranging from 30 minutes to 4 hours. Recovering Petri Dishes: After the specified exposure time ends, quickly cover the Petri dish lids and recover the Petri dishes in sequence according to the sampling points. Pay attention to avoiding collisions and contamination of the Petri dishes during the recovery process. Cultivation: Put the recovered Petri dishes into a constant - temperature incubator in a timely manner. Set appropriate culture temperature and time according to the characteristics of the culture medium and relevant standard requirements, generally cultivate at 30 - 35°C for 48 hours. Counting and Recording: After the cultivation is completed, count the colonies in the Petri dishes in a sterile environment. Adopt appropriate counting methods, such as direct visual counting or with the help of colony counters and other tools. Accurately record the number of colonies at each sampling point and fill it in the pre - prepared record form. Precautions Aseptic Operation: The entire testing process must strictly follow the aseptic operation principle to avoid introducing new microbial contamination during the operation. Environmental Monitoring: During the test, monitor and record the environmental parameters such as temperature, humidity, and pressure difference in the purification workshop at the same time for reference when analyzing the test results later. Data Processing: Statistically analyze the number of colonies obtained from the test to determine whether it meets the settling bacteria standard requirements of the pharmaceutical plant purification workshop. If abnormal data is found, find the reasons in time and conduct a review. Mastering the standard operating procedure for settling bacteria testing in pharmaceutical plant purification workshops is an important measure to ensure that the drug production environment meets the requirements. Guangzhou Cleanroom Construction Co., Ltd. is always committed to providing high - quality purification equipment and technical support for pharmaceutical factories and other customers, helping the pharmaceutical production industry create a high - quality production environment. If you have any questions or needs regarding settling bacteria testing or purification workshop construction, please feel free to contact us at any time!
2025-01-23
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