Cases - Guangzhou Cleanroom Construction Co., Ltd. of page 11

In biopharmaceutical workshops, the refrigeration station group system is as crucial as the human body's thermoregulatory system is to maintaining life. The production process of biopharmaceuticals has extremely stringent requirements for environmental conditions such as temperature and humidity. The refrigeration station group system shoulders the important task of ensuring a stable production environment and guaranteeing the quality and safety of drugs. If the temperature control is improper, the active ingredients of drugs may become inactive, and the cultivation environment for microorganisms may be damaged, thereby affecting the efficacy of drugs. In severe cases, it may even lead to the scrapping of an entire batch of drugs, causing huge losses. I. Composition of the Refrigeration Station Group System (I) Chiller Units: The Core of Refrigeration Chiller units can be regarded as the "heart" of the refrigeration station group system. Through a series of refrigeration cycles including compression, condensation, throttling, and evaporation, they compress low-temperature and low-pressure refrigerant gas into high-temperature and high-pressure gas. After heat dissipation in the condenser, it becomes high-pressure liquid, and then the pressure is reduced through the throttling device. In the evaporator, it absorbs the heat of the chilled water, reducing the temperature of the chilled water and bringing "coolness" to the workshop. In biopharmaceutical workshops, centrifugal chiller units are commonly used because of their large cooling capacity and high efficiency, which meet the high demand for cooling capacity in large-scale production. (II) Pumps: The Drivers of Circulation Pumps are like the "blood vessels" of the refrigeration station group system, responsible for pushing the chilled water and cooling water to circulate within the system. The chilled water pumps transport the low-temperature chilled water to various areas in the workshop that require refrigeration. After absorbing heat and increasing in temperature, it is sent back to the evaporator of the chiller unit for recooling. The cooling water pumps transport the cooling water that has absorbed heat from the condenser to the cooling tower for heat dissipation and temperature reduction, and then it returns to the condenser for recycling. Nowadays, variable-frequency pumps are widely used in biopharmaceutical workshops. They can automatically adjust the rotation speed according to the system load, achieving significant energy-saving effects. They can also precisely control the water flow, ensuring the stable operation of the system. (III) Cooling Towers: Key Heat Dissipation Equipment Cooling towers can be called the "heat dissipation masters" of the refrigeration station group system. Their main function is to dissipate the heat carried by the cooling water into the atmosphere, reducing the temperature of the cooling water. In biopharmaceutical workshops, counterflow cooling towers are often used. They utilize the counterflow of air and water to increase the contact area and time, achieving efficient heat dissipation. At the same time, the cooling towers are equipped with intelligent control systems, which can automatically adjust the rotation speed of the fans according to the ambient temperature and the temperature of the cooling water, ensuring the heat dissipation effect while saving electricity. II. Operation Mechanism of the Refrigeration Station Group System (I) Intelligent Group Control Technology: The "Smart Brain" of the System Intelligent group control technology endows the refrigeration station group system with "intelligence" and serves as the "brain" of the entire system. It collects data such as the temperature, humidity, and cooling load of the workshop in real-time through sensors, as well as the operation parameters of equipment such as chiller units, pumps, and cooling towers. Using advanced algorithms for analysis and processing, it precisely controls the operation status of each device. For example, when the cooling load of the workshop decreases, the intelligent group control system will automatically reduce the number of operating chiller units and lower the rotation speeds of the pumps and cooling tower fans, minimizing energy consumption while meeting the refrigeration demand. (II) Load Regulation Strategy: Precise Adaptation to Requirements In biopharmaceutical workshops, the cooling load requirements of different production processes fluctuate greatly. The refrigeration station group system adopts flexible load regulation strategies to precisely adapt to these changes. Chiller units have multi-stage energy regulation functions and can automatically adjust the cooling capacity output according to the size of the cooling load. Pumps and cooling tower fans can also change the flow rate and air volume through variable-frequency speed regulation to achieve dynamic matching with the cooling load. For instance, during the drug fermentation stage, which has high requirements for temperature control and a large cooling load demand, the system will operate at full capacity. In the drug packaging stage, when the cooling load demand is small, the system will automatically operate with reduced energy consumption. III. Innovative Technological Applications of the Refrigeration Station Group System (I) Internet of Things (IoT) Technology: Achieving Remote Monitoring and Management IoT technology has brought the refrigeration station group system into a new era of remote monitoring and management. By installing intelligent sensors and communication modules on the equipment, the operation data of the equipment is uploaded to the cloud platform in real-time. Managers can view the operation status of the system anytime and anywhere through terminals such as mobile phones and computers, operate the equipment remotely, and handle fault alarms in a timely manner. This not only improves management efficiency but also enables the prediction of potential equipment failures in advance, facilitating preventive maintenance and reducing downtime. (II) Big Data Analysis and Predictive Maintenance: Ensuring Stable Equipment Operation The application of big data analysis technology in the refrigeration station group system provides a safeguard for the stable operation of the equipment. The system collects a large amount of historical operation data of the equipment and uses big data analysis algorithms to uncover the patterns behind the data and establish equipment performance models. By comparing the real-time data with the predicted values of the models, potential fault hazards of the equipment can be detected in advance, and preventive maintenance can be arranged. For example, if it is predicted that the bearing of a certain pump may fail in a week, maintenance and replacement can be arranged in advance to avoid production interruptions caused by sudden failures. IV. Advantages of the Refrigeration Station Group System (I) High Efficiency and Energy Saving: Reducing Operating Costs The refrigeration station group system achieves high efficiency and energy saving through the application of intelligent group control technology, load regulation strategies, and energy-saving equipment, significantly reducing the operating costs of biopharmaceutical workshops. Compared with traditional refrigeration systems, it can save 30% - 50% of energy consumption. Taking a large biopharmaceutical workshop as an example, it can save several million yuan in electricity bills every year. In the long run, the economic benefits are remarkable. (II) Precise Temperature Control: Guaranteeing Drug Quality Precise temperature control is the lifeline of biopharmaceutical workshops, and the refrigeration station group system performs excellently in this regard. It can control the temperature of the workshop within ±0.5°C and the humidity within ±5%, providing a stable environment for drug production. During the vaccine production process, precise control of temperature and humidity can ensure the activity and stability of the vaccine, improving the quality and safety of drugs. V. Key Points of Maintenance and Management of the Refrigeration Station Group System (I) Regular Inspections and Maintenance: Extending Equipment Lifespan Regular inspections and maintenance are the keys to ensuring the long-term stable operation of the refrigeration station group system and extending the lifespan of the equipment. Maintenance personnel need to conduct comprehensive inspections of equipment such as chiller units, pumps, and cooling towers according to the specified inspection cycles, including equipment appearance, operation parameters, and connecting components. Regularly add lubricating oil to the equipment, replace vulnerable parts, and clean the condensers and evaporators. Generally, chiller units are comprehensively maintained once a quarter, and pumps and cooling towers are inspected and maintained once a month. (II) Fault Diagnosis and Troubleshooting: Quickly Restoring Production When a fault occurs in the refrigeration station group system, quick and accurate fault diagnosis and troubleshooting are of great importance. Maintenance personnel should rely on the built-in fault diagnosis system of the equipment, data from intelligent sensors, and their own experience to quickly determine the cause and location of the fault. For common faults such as pump motor overload and cooling tower fan failure, spare parts should be prepared for timely replacement and repair. For complex faults, technical support from the manufacturer should be contacted in a timely manner to restore the normal operation of the system as soon as possible and minimize the impact on production.

In the food industry, the safety and standardization of the production environment are directly related to consumers' health. Singapore Standard SS 585:2017 Design Standards for Food Factories serves as a crucial guideline for the construction and renovation of food factories in Singapore, safeguarding food safety from multiple dimensions. Guangzhou Cleanroom Construction Co., Ltd. has conducted in-depth research on and actively implemented this standard, leveraging its professional capabilities to assist food enterprises in creating compliant and efficient production spaces. I. In-depth Interpretation of the Core Provisions of SS 585:2017 The SS 585:2017 standard covers various aspects of food factories, including site selection, layout, facilities and equipment, and hygiene management. These provisions work in tandem to establish a rigorous defense line for food safety production. (I) Site Selection Requirements Clause Classification Specific Requirements Key Data/Indicators Design Principles Site Selection Requirements Keep a distance from pollution sources such as waste disposal sites and chemical plants; the terrain should be higher than the surrounding areas to prevent waterlogging Distance from pollution sources should be ≥ 500 meters; terrain height difference is recommended to be ≥ 0.5 meters Prevent external pollutants from entering the factory through air, water, and other means, which may affect food raw materials and the production environment. A higher terrain is conducive to natural drainage, reducing the impact of floods on the factory (II) Workshop Layout Regarding workshop layout, in addition to clearly separating production areas, storage areas, and office areas, and having independent pedestrian and logistics channels, the cleanliness levels of different functional areas also need to match production requirements. For example, the cleanliness level of food processing areas is usually higher than that of raw material storage areas. Meanwhile, the setup of buffer zones between areas is of great importance. Buffer zones should be equipped with handwashing and disinfection facilities, air showers, etc., effectively preventing pollutants carried by personnel and materials from entering high - cleanliness areas. Clause Classification Specific Requirements Key Data/Indicators Design Principles Workshop Layout Clearly separate production areas, storage areas, and office areas; have independent pedestrian and logistics channels; set up buffer zones in different functional areas Physical partitions are required for separation of different functional areas; the width of the channels should be ≥ 1.5 meters; the area of the buffer zone should be ≥ 6 square meters Physical partitions and independent channels avoid cross - contamination of pedestrians and logistics; buffer zones can purify personnel and materials entering high - cleanliness areas (III) Air Purification Air purification in clean workshops is the key to ensuring food safety. SS 585:2017 stipulates that the cleanliness of areas in direct contact with food is recommended to reach ISO Class 8. To achieve this goal, not only high - efficiency filters are required, but also a reasonable design of air flow organization. Turbulent flow cleanrooms usually adopt a top - supply and bottom - return air flow form, which can effectively dilute indoor pollutants; while unidirectional flow cleanrooms discharge pollutants quickly through the principle of piston flow. Clause Classification Specific Requirements Key Data/Indicators Design Principles Air Purification Clean workshops need to reach the corresponding cleanliness level; regularly detect air cleanliness and microbial content The cleanliness of areas in direct contact with food is recommended to reach ISO Class 8; conduct a comprehensive inspection at least once a quarter High - efficiency filtration and scientific air flow organization ensure clean air, and regular inspections ensure that the purification effect remains up to standard (IV) Temperature and Humidity Control Different types of food have varying requirements for temperature and humidity. Take the baking industry as an example. The raw material storage area needs to be kept dry, with a humidity control of 50% - 60% to prevent raw materials such as flour from getting damp and caking. In the cold storage area of meat processing, the temperature should be controlled at 0 - 4°C, and the humidity at 60% - 70%, which can not only inhibit the growth of microorganisms but also prevent meat from dehydration and deterioration. Clause Classification Specific Requirements Key Data/Indicators Design Principles Temperature and Humidity Control Set appropriate temperature and humidity ranges according to the type of food; the fluctuation range of temperature and humidity needs to be within a controllable interval Temperature control in the cold storage area at 0 - 4°C, humidity at 60% - 70%; temperature fluctuation ± 1°C, humidity fluctuation ± 5% Precise temperature and humidity control creates a suitable environment for food storage and processing, reducing the risk of quality changes (V) Drainage System The slope design of drainage pipes directly affects drainage efficiency. A slope of ≥ 2% for drainage pipes ensures the rapid discharge of sewage, preventing water accumulation and the breeding of bacteria. At the same time, filters and P - traps should be installed at drainage outlets. Filters can intercept solid waste to prevent pipe blockages, and P - traps can prevent the backflow of odors and harmful gases from the sewer into the workshop. Clause Classification Specific Requirements Key Data/Indicators Design Principles Drainage System Drainage pipes need to have a slope to prevent water accumulation; install filters and P - traps at drainage outlets The slope of drainage pipes should be ≥ 2%; the pore size of the filter should be ≤ 5mm Reasonable slope and drainage outlet facilities ensure smooth drainage and prevent workshop environmental pollution II. Rich Application Examples and Remarkable Effects of the Standard (I) Renovation Project of a Baking Food Factory in Singapore Before the introduction of the SS 585:2017 standard, the factory had several problems. The raw material storage area was too close to the processing area, and there was no effective partition, so raw materials like flour were prone to absorbing odors generated in the processing area. The workshop ventilation system was imperfect, resulting in high air humidity, and some baked products became damp. After re - planning according to the standard, the raw material storage area was moved to an independent area, and moisture - proof and odor - proof partition doors were installed. A fresh air system combined with high - efficiency filters was adopted to improve the air quality in the workshop and strictly control the humidity. Meanwhile, the production process was optimized to enable a one - way flow of raw materials from the storage area to the processing area and then to the finished product area. After the renovation, the damp rate of products decreased from 12% to 3%, and the odor complaint rate decreased by 85%. The production environment was greatly improved, and product quality was significantly enhanced. (II) Upgrading Project of a Meat Processing Factory in Singapore The factory's original temperature and humidity control system was outdated, unable to precisely control the temperature in the cold storage area, resulting in thawing and refreezing of some meat products, which affected the meat quality and shelf life. In addition, the drainage system had problems such as insufficient pipe slope and the lack of filtration devices at drainage outlets, leading to poor sewage discharge and frequent water accumulation on the workshop floor. After upgrading according to the SS 585:2017 standard, an intelligent temperature and humidity control system was installed, which can monitor and adjust temperature and humidity in real - time. The drainage pipes were re - laid to ensure that the slope met the standard, and filters and P - traps were added at the drainage outlets. After the renovation, the microbial over - standard rate of products decreased from 8% before the renovation to 1.2%, production efficiency increased by 15%, and product losses caused by temperature and humidity problems were reduced by 20%. Both economic benefits and food safety levels were significantly improved. III. Guangzhou Cleanroom Construction Co., Ltd.: A Deep Practitioner of the SS 585:2017 Standard (I) Air Purification Solutions The high - efficiency air purification equipment developed by Guangzhou Cleanroom Construction Co., Ltd. uses H13 - grade high - efficiency filters, with a filtration efficiency of 99.99% for particles of 0.3μm, stably ensuring that the air cleanliness of the workshop reaches ISO Class 8 or even higher standards. Meanwhile, the company has a professional air flow organization design team that can design the most reasonable air supply and return schemes according to the workshop layout and production requirements. For example, in large - scale food processing workshops, the air flow organization form of top - side supply and double - side bottom - return is adopted, effectively avoiding air flow dead corners and ensuring the uniform distribution of clean air. (II) Temperature and Humidity Control System The company's temperature and humidity control system has high - precision regulation capabilities, with a temperature control accuracy of ± 0.5°C and a humidity control accuracy of ± 3%. It can customize personalized solutions according to different food production needs. For example, the temperature and humidity control system designed for chocolate production workshops can stably control the workshop temperature at 18 - 22°C and humidity at 40% - 50% in high - temperature summer environments, preventing chocolate from melting and frosting on the surface and ensuring product quality. (III) Overall Planning and Services In addition to supplying core equipment, Guangzhou Cleanroom Construction Co., Ltd. also provides one - stop services covering pre - construction planning and design, equipment installation and commissioning, and after - sales maintenance. In the planning and design stage, the company's team will thoroughly understand the production processes, product types, and other information of food enterprises, and conduct scientific and reasonable workshop layout planning in combination with the SS 585:2017 standard, including functional area division, design of pedestrian and logistics channels, and layout of ventilation and drainage systems. During the installation and commissioning process, every link is strictly controlled to ensure stable equipment operation and that all indicators meet the standard requirements. In terms of after - sales maintenance, regular inspection services are provided to promptly detect and solve problems that occur during equipment operation, ensuring the continuous compliant production of food factories. With years of industry experience and a professional technical team, the company has successfully assisted more than 50 food enterprises in completing factory upgrading and renovation projects, receiving unanimous praise from customers. Adhering to Singapore Standard SS 585:2017 Design Standards for Food Factories is the key for food enterprises to achieve safe production and enhance their market competitiveness. Guangzhou Cleanroom Construction Co., Ltd. is willing to join hands with food enterprises with its professional capabilities to jointly create food production environments that meet high standards, safeguard the food safety defense line, and contribute to the healthy development of the food industry.

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