latest company case about Guangzhou Cleanroom Construction Co., Ltd. Certifications

The safety, regulatory compliance, and reliability of research data in animal laboratories fundamentally depend on the level of environmental control. Among all infrastructure systems, the exhaust and waste gas filtration system is not merely a basic utility but a critical line of defense for risk control. It directly affects occupational health, animal welfare, experimental accuracy, and the laboratory’s environmental and community responsibilities.

This system must address four key challenges:

Effectively remove aerosols that may contain pathogenic microorganisms, preventing cross-contamination within the laboratory and biological leakage to the external environment.

Eliminate irritating gases such as ammonia and hydrogen sulfide generated by animal metabolism, as well as volatile organic compounds (VOCs) and particulate matter produced during experimental procedures.

Through stable supply and exhaust air control, ensure reliable pressure differentials between clean areas, barrier zones, and negative-pressure isolation areas, thereby achieving directional airflow control.

Deeply treat exhaust air to eliminate odors and ensure compliance with increasingly stringent national and local environmental emission regulations, minimizing disturbance to surrounding communities.

A high-performance and reliable system typically adopts a staged treatment strategy with multiple layers of protection.

Function: Protect downstream high-efficiency filtration units and extend their service life.
Typical Configuration:
Coarse filters (G4) and medium-efficiency filters (F8) to capture animal hair, large particles, and dust.

Chemical Filtration Unit:
Designed for specific gaseous contaminants. Impregnated activated carbon or specialized chemical media are used to remove acidic/alkaline gases, VOCs, and characteristic odors through adsorption, catalytic, or neutralization reactions.

High-Efficiency Particulate Air Filtration (HEPA/ULPA):
The cornerstone of biological safety protection. H14-grade HEPA filters achieve ≥99.995% efficiency for particles ≥0.3 μm, effectively capturing the majority of bacteria and virus carriers. ULPA filters may be applied in areas with higher containment requirements.

Variable Frequency Fan Systems:
Automatically adjust airflow based on the number of operating fume hoods or pressure variations, ensuring safety while optimizing energy efficiency.

Constant Air Volume (CAV) and Variable Air Volume (VAV) Dampers:
Precisely regulate airflow to individual rooms or branches, maintaining stable pressure differentials.

Real-Time Monitoring and Alarms:
Continuous monitoring of key parameters such as filter differential pressure, room pressure differentials, and fan operating status, with immediate alarms under abnormal conditions to ensure full system control.

Heat Recovery Devices:
Plate heat exchangers, rotary heat wheels, or heat pipe systems installed between exhaust and supply air streams significantly reduce HVAC energy consumption.

Safe Exhaust Discharge:
After multi-stage treatment, purified air is discharged through independent exhaust stacks at high elevation to meet dispersion and environmental safety requirements.

Define laboratory biosafety level (ABSL-1 / ABSL-2 / ABSL-3), animal species, cage density, and experimental characteristics. This forms the basis for all subsequent design calculations.

Design must strictly comply with applicable national standards such as GB 14925 – Laboratory Animals: Environment and Facilities, GB 50746 – Technical Code for Biosafety Laboratory Buildings, as well as building fire protection codes and local environmental regulations.

Perform detailed airflow calculations, pressure differential simulations, and airflow organization analysis, often supported by Computational Fluid Dynamics (CFD), to ensure feasibility and optimal system performance.

A complete system should be supported by full documentation and testing, including Design Qualification (DQ), Installation Qualification (IQ), Operational Qualification (OQ), and Performance Qualification (PQ). This is the foundation for regulatory acceptance and laboratory accreditation.

• Safety Redundancy:
  Are backup fans and power supplies provided for critical areas? Are there redundant protections and alarms for filter failure?

• Life-Cycle Cost:
  Beyond initial investment, evaluate energy consumption, filter replacement costs, and ease of maintenance.

• Scalability and Flexibility:
  Can the system accommodate future laboratory layout changes or process upgrades?

• Supplier Capabilities:
  Does the provider offer integrated expertise in design, construction, commissioning, and long-term maintenance, supported by proven project experience?

Exhaust and waste gas filtration systems in animal laboratories are far more than simple ventilation equipment. They are complex life-safety systems integrating biosafety engineering, HVAC, automation control, and environmental engineering. A well-designed and properly implemented system proactively controls risks at the source, creating an “invisible yet absolutely reliable" protective barrier for scientific research.

In both new laboratory construction and renovation projects, investing in and prioritizing the professionalism of these systems is a direct commitment to personnel safety, research integrity, environmental responsibility, and social accountability.